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(6月20日):Seamless phase II/III clinical trials with frequentist response adaptive randomization
来源: 陈黎   发布时间:2017-6-19   阅读次数:172

报告题目:Seamless phase II/III clinical trials with frequentist response adaptive randomization

演讲人:    Dr. Hongjian Zhu (朱宏建)

                    University of Texas Health Science Center at Houston

时间地点:2017620日(星期二)下午 2:00-3:00

工商管理楼二楼多媒体厅(200-9)

 

摘要: Seamless phase II/III clinical trials have attracted increasing attention recently. They mainly use Bayesian response adaptive randomization (RAR) designs. There has been little research into seamless clinical trials using frequentist RAR designs because of the difficulty in performing valid statistical inference and controlling the type I error rate for this procedure. Well-designed frequentist RAR can target theoretically optimal allocation proportions, and they have explicit asymptotic results. We propose a family of frequentist RAR designs for seamless phase II/III clinical trials, study its asymptotic properties, and investigate how to control the type I error rate. The numerical studies demonstrate that the type I error rate can be well controlled with the proposed method and certain ethical and efficient objectives can be achieved using the proposed design.

 

欢迎大家参加!

演讲人简介:朱宏建,2005年毕业于浙江大学混合班,获得统计学专业理学学士学位,2010年毕业于美国弗吉尼亚大学统计系,获得博士学位。2010-2012年在耶鲁大学赵宏宇教授实验室做博士后。2012年至今,在University of Texas Health Science Center at Houston Assistant Professor. 

朱宏建博士主要研究方向包括临床试验设计和统计方法在医学中的应用,在国际著名刊物上发表论文20余篇,其中包括Annals of Statistics, JASA等统计杂志,和JACC等医学杂志。获得美国统计协会ASA颁发的SIE award,和美国数学协会AMS颁发的AMS Simon Award.

 

联系人:张立新 stazlx@浙大

 

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