Prediction and Inference under Competing Risks in High Dimension - An EHR Demonstration Project for Prostate Cancer

浙江大学数学科学学院九十周年院庆系列活动之八十七

报告题目： Prediction and Inference under Competing Risks in HighDimension - An EHR Demonstration Project for Prostate Cancer

报告人： RonghuiXu,  Dr./ Professor

Professor of Statistics and Biostatistics

Department of Family Medicine and Public Health

and Department of Mathematics

University of California

时间地点：2018年10月23日(星期二)下午4:00开始

浙江大学玉泉校区工商管理楼二楼200-9报告厅

摘要： The work was motivated by the analysis project using the linkedSEER-Medicare database to predict cancer versus non-cancer mortality in men ofage 65 years or older who were diagnosed with prostate cancer. We considerexisting R package implementations that are computationally feasible for suchdata sets with up to 100,000 human subjects and over 20,000 claim codes. Wecarried out simulation studies to compare lasso for cause-specific hazardsregression and boosting for Fine-Gray sub-distribution regression models withdifferent approaches to choosing the penalty parameters, with the goal ofprediction accuracy of the cumulative incidence rates at 2 and 5 years frombaseline. Separately, we also developed methods for constructing confidenceintervals of the regression effects of predictors (clinical variables and claimcodes) under the Fine-Gray model in high dimensions, using the one-step estimator alongthe line of van de Geer et al. (2014) and Zhang and Zhang (2014). The extensionthough, is non-trivial under competing risks and Cox type modelformulation. The results of the SEER-Medicare database analysis willbe presented..

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联系人: 张立新教授 stazlx@zju.edu.cn

浙江大学数据科学研究中心、浙江大学统计学研究所

报告人简介：Dr. Xu received both her Masters in Applied Mathematics (1995) and herPhD in Mathematics (1996) from UCSD. She worked for one year as a POST-graduateresearcher at the UCSD Cancer Center and the Department of Mathematics beforetaking up an Assistant Professorship in 1997 in the Department ofBiostatistics, Harvard School of Public Health and the Department ofBiostatistical Science, Dana-Farber Cancer Institute in Boston, MA. Shereturned to UCSD in 2004 as an Associate Professor with the Department of FamilyMedicine and Public Health and the Department of Mathematics. She is arecipient of David P. Byar Young Investigator Award, and fellow, AmericanStatistical Association.

Dr. Xu directs the Biostatistics unit at the UCSDClinical and Translational Research Institute (CTRI), partially funded by theNIH Clinical and Translational Science Award (CTSA). She is the leadstatistician at the Organization of Teratology Information Specialists (OTIS)Collaborative Research Center, which carry out studies such as the FetalAlcohol Spectrum Disorders Prevalence in the US and Vaccine and Medication inPregnancy Surveillance System.